About Us
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The Broome Lab integrates biology, chemistry, and physics to bioengineer molecular imaging agents and bio-mimetic drug delivery vehicles. Our research team combines expertise in areas of nanoparticle design, cell engineering, biomarker imaging, immunology, surgery, and oncology in order to develop multi-functional nanoparticles. The overarching mission is to create personalized multi-functional nanotherapeutics and therapy detection and monitoring tools with an emphasis on the development of a reliable nanotechnology-based solution for those organs where disease is characterized by low survival rates. |
2017
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Dr. Broome
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Dr. Ann-Marie Broome is the Director of Advanced Nanodelivery, Director of Small Animal Imaging in the Hollings Cancer Center and the Director of Molecular Imaging in the Center for Biomedical Imaging at the Medical University of South Carolina (MUSC). Dr. Broome's research focuses on bio-inspired nanotechnology, pharmaceutical engineering, and theranostic agents to facilitate detection, diagnosis, assessment, and treatment outcomes. She joined the faculty of the College of Medicine at MUSC in 2012, where she held appointments in the Departments of Radiology & Radiological Science and Neuroscience. Since 2016, Dr. Broome holds an appointment in the Department of Cell and Molecular Pharmacology & Experimental Therapeutics. She also holds an appointment in the Department of Bioengineering at Clemson University. She is co-Founder and CEO of biotech start-up ToleRaM Nanotech.
Dr. Broome has authored more than 50 peer-reviewed journal articles, reviews, book chapters, and patents. Research in the Broome Lab is funded through grants from federal agencies, including the National Institutes of Health, Department of Defense, Department of Veterans Affairs, and National Science Foundation, as well as private foundations, including the American Cancer Society. Dr. Broome, as PI or Co-PI, has been awarded grants totaling over $12.5 million in total costs during her career. |
Dr. Broome graduated from Columbia College with a B.S. in chemistry, biology, and mathematics. She received her doctoral degree in biomedical sciences from the University of South Carolina establishing the presence and function of unique cell surface markers involved in spermatogenesis and spermiogenesis under the tutelage of Dr. Clarke Millette (1998). She then completed a postdoctoral fellowship with Dr. Richard Eckert at Case Western Reserve University (CWRU), where she worked on the protein interactions and translocation dynamics of the calcium-regulated S100 proteins during epidermal differentiation and disease (1999-2002). In 2003, she was promoted to Instructor in the Department of Physiology and Biophysics at CWRU. As a NIH NIBIB K01 awardee (2005), Dr. Broome transitioned to the Department of Biomedical Engineering in the School of Engineering at CWRU as an Assistant Professor, working with her mentor Dr. James Basilion on the development of imaging nanoparticles for molecular imaging. Concurrently as BME Faculty, she received her M.B.A. from Weatherhead School of Management in Bioscience Entrepreneurship and in Healthcare Management Systems (2008).
